Disulfiram Induced Psychosis
نویسندگان
چکیده
Disulfiram is the commonly prescribed drug for the treatment of alcohol dependence. It's major metabolite (diethyldithiocarbamate) is an inhibitor of dopamine-betahydroxylase, an enzyme that catalyzes the metabolism of dopamine to norepinephrine resulting in psychosis. We recommend that disulfiram should be used at the lowest effective dose, possibly 250 mg daily and caution should be taken while prescribing disulfiram for patients with personal and familial antecedents of psychosis.
منابع مشابه
A Case of Psychosis in Disulfiram Treatment for Alcoholism
Background. Disulfiram, a drug used in the treatment of alcohol dependence, is an inhibitor of dopamine- β -hydroxylase causing an increase in the concentration of dopamine in the mesolimbic system. In addition to the physical symptoms associated with concomitant use of alcohol, disulfiram may lead to adverse events, when used alone, including psychosis. Aims. To report a case of a rare complic...
متن کاملComment on: Disulfiram Induced Psychosis (Mohapatra and Rath, Clin Psychopharmacol Neurosci 2017;15:68-69)
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Comment on: Disulfiram Induced Psychosis (Mohapatra and Rath, Clin Psychopharmacol Neurosci ...
متن کاملDisulfiram-induced delirium: diagnostic dilemma
Disulfiram, a useful medication to deter the relapse of alcohol dependence, has been associated with a number of neuropsychiatric adverse effects. Disulfiram induced delirium is rare in the absence of an ongoing psychosis or a disulfiramethanol reaction. We present the case of an alcohol dependent patient who had a past history of both an alcohol-induced psychotic episode (which had resolved co...
متن کاملE.c.t. Induced Catationia: a Case Report
For a long time catatonic signs were considered to be the specific features of schizophrenia (Vogdt 1958). It soon became clear that such features may occur in functional psychoses other than schizophrenia and in fact, may even be more common in affective psychosis than schizophrenia (Abram & Taylor 1976). Apart from functional disorders like schizophrenia, affective psychosis and hysteria, a c...
متن کاملInhibition of ifosfamide-induced urotoxicity by disulfiram in mice.
The effect of disulfiram on the urotoxicity induced by ifosfamide was studied in mice. Ifosfamide administered intraperitoneally to mice caused a dose-related increase in bladder weight within 48 hr of treatment. Disulfiram prevented ifosfamide-induced bladder damage when administered orally within 1 hr of ifosfamide treatment. The results indicate that disulfiram is an effective protective age...
متن کامل